Coumarins and derivatives
eMolecules 28448-04-6 | Medchem Express | 3-Nitrocoumarin | 5mg | 485251314 | HY-111919 | MFCD00233577 | 191.142 | C9H5NO4
Ambeed | 2356-Tetramethylterephthalaldehyde | 100mg | 633662595 | A400040 | 7072-01-7 | MFCD00194529 | 190.242 | C12H14O2
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Apexbio Technology LLC Palomid 529 914913-88-5 50mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 1 MG
AZP-531 is an analogue of unacylated ghrelin for research use, designed to improve glycaemic control and reduce weight. It shows survival effects on pancreatic β-cells and human pancreatic islets, and is highly stable in human plasma in vitro with no degradation after one day at 37°C.
- Exhibits survival effects on pancreatic β-cells and human pancreatic islets.
- Stable in human plasma in vitro at 37°C for one day.
- Prevents high-fat diet-induced weight gain, proinflammatory effects, and prediabetic metabolic state in mice.
- Stimulates mitochondrial function markers in brown adipose tissue.
- Well-tolerated in clinical trials; improves glucose without increasing insulin.
- Reduces mean body weight and HbA1c in clinical trials.
Selleck Chemical LLC 7-Methoxycoumarin S5163-25mg
7-Methoxycoumarin (Herniarine) also known as Herniarin is a methoxy derivative of coumarin and substrate for dealkylase It has been used in the synthesis of anti-first-pass effect compounds and detergents
Medchemexpress LLC Coumarin 314 | 55804-66-5 | MFCD00051334 | 98.0% | 313.35 g·mol⁻¹ | C18H19NO4 | 100 MG
Coumarin 314 is a fluorescent dye exhibiting strong absorption in the visible region and pronounced solvent-dependent spectral properties. It is supplied as a light yellow solid and is used primarily as a research reagent in fluorescence measurements, probe design, and photophysical studies.
- Strong visible absorption and fluorescence.
- Pronounced solvent-dependent spectral behavior.
- High purity for research applications.
- Light yellow solid appearance for easy handling and identification.
- Suitable for photophysical and fluorescence probe studies.
Sigma Aldrich Fine Chemicals Biosciences 7-Methoxycoumarin suitable for fluorescence, >=98.0% (TLC) | 531-59-9 | MFCD00006876 | 100MG
7-Methoxycoumarin suitable for fluorescence, >=98.0% (TLC) | Purity: >=98.0% (TLC) | Mol Wt: 176.17 | 531-59-9 | MFCD00006876 | 100MG
![Medchemexpress LLC Methanesulfonamide, N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]- | 2791417-66-6 | 99.9% | 453.94 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000395426.png-250.jpg)
Medchemexpress LLC Methanesulfonamide, N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]- | 2791417-66-6 | 99.9% | 453.94 | 25 MG
MTX-531 is an oral drug that inhibits EGFR and PI3K, demonstrating anti-tumor effects. It also acts as a weak agonist of PPARγ, helping to alleviate hyperglycemia induced by PI3K inhibitors. This compound shows good tolerability in in vivo studies, without causing hyperglycemia, a common side effect of PI3K inhibitors.
- Inhibits EGFR with an IC50 of 14.7 nM, and PI3K with IC50 values ranging from 1.1 nM to 233 nM.
- Demonstrates anti-tumor effects, suppressing tumor proliferation and growth.
- Acts as a weak agonist of PPARγ with an IC50 of 2.5 μM, which helps to alleviate hyperglycemia.
- Indicates excellent tolerance in mice and the absence of hyperglycemia in vivo.
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | 97.0% | 220.18 | C11H8O5 | 250 MG
7-Methoxycoumarin-3-carboxylic acid is a coumarin-based fluorescent dye used to derivatize molecules for fluorescence detection in biochemical assays. It is commonly applied to label peptides, for HPLC derivatization, and for development of fluorescent probes.
- Fluorescent coumarin dye with characteristic excitation and emission peaks.
- Excitation ~345-355 nm; emission ~405-450 nm.
- High purity (manufacturer lists 97.0%).
- Chemical formula C11H8O5; molecular weight 220.18.
- Available in multiple sizes from 250 mg to 50 g.
- Suitable for peptide labeling and HPLC derivatization.
- Supplied with data sheet and safety data sheet (SDS).
Cayman Chemical 3azido7hydroxy Coumarin
A click-reactive fluorescent dye; Upon CuAAC in a biological system, a fluorescent product is produced that displays excitation/emission maxima of 404 and 477 nM, respectively; has been used for spatially restricted metabolite labeling and the detection of foodborne pathogens
eMolecules 90349-18-1 | 4-(Ethylamino)-3-nitrobenzonitrile | MFCD00186035 | 1g
Combi-Blocks | 4-(Ethylamino)-3-nitrobenzonitrile | 1g | 205380622 | AN-1541 | 96.000 | 90349-18-1 | MFCD00186035 | 191.190 | C9H9N3O2
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eMolecules 6-Fluoro-4-hydroxycoumarin | 1G | Ships from Wood Dale, IL | Chem-Impex | 1994-13-4 | MFCD03094006 | MW: 180.13
Chem-Impex | 6-Fluoro-4-hydroxycoumarin | 1G | 1994-13-4 | MFCD07383035 | MW:177.22
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Selleck Chemical LLC Esculetin S4711-1g
Esculetin (Cichorigenin Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema anti-inflammatory and anti-tumour effects It inhibits lipoxygenases (LOs)
eMolecules 135-91-1 | 4,4'-Methylenebis(N,N-diethylaniline) | ChemScene | MFCD00071778 | 310.485 | C21H30N2 | 97.000 | CCN(CC)c1ccc(Cc2ccc(cc2)N(CC)CC)cc1 | 1g | 591908855
4,4'-Methylenebis(N,N-diethylaniline) | ChemScene | 135-91-1 | MFCD00071778 | 310.485 | C21H30N2 | 97.000 | CCN(CC)c1ccc(Cc2ccc(cc2)N(CC)CC)cc1 | 1g | 591908855